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A phase 2b randomized, double-blind, vehicle-controlled, repeat-dose, multi- center, efficacy and safety clinical trial of topically applied OLT1177 gel in subjects with moderate to severe pain associated with osteoarthritis of the knee following cessation of pain therapy (2017)

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Using siRNA or chemical inhibitors to inhibit GPX4 leads to the accumulation of lipid peroxidation, causing ferroptosis in H9c2 cardiomyocytes

136 Dysregulation of these adipokines has been implicated in the onset of obesity, IR, type 2 diabetes, cardiovascular disease, hypertension and metabolic syndromes

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